Completed project: Indiana CTSI Hub (EP Action Items 4, 6, 16, 70, 71)

Primary UITS contact: William Barnett, Research Technologies

Completed: November 13, 2014

Description: The goal of this project is to develop an Indiana CTSI Hub portal based on the HUBzero software architecture. The Indiana Clinical and Translational Science Institute (CTSI), based on a $25 million National Institutes of Health Clinical and Translational Science Award (CTSA), was announced on May 29, 2008, as a partnership between IU and Purdue. The HUBzero platform uses the Joomla! web content management system.

In October 2007, the Hub went live and was running when the award was announced in May 2008. In September 2009, the Hub was awarded an ARRA supplement to the Indiana CTSI award to enhance Hub tools, NIH grant #3UL1RR025761-02S3.

Hubs represent a Web 2.0 approach to research collaboration, education, and research program implementation, as well as access to national supercomputing and other IT resources.

Outcome: The CTSI Hub is designed to be the central clearinghouse for translational research activities for health care researchers at the IU School of Medicine and ultimately across the state of Indiana. It is a statewide laboratory for transforming health sciences research and health care delivery. The goals of the CTSI are to create research acceleration programs and support pilot projects, train a new cadre of translational researchers, foster robust community engagement, build facile and comprehensive resources and technologies, and leverage the resources of the greater Indiana community.

Milestones and status: The Indiana CTSI Hub has been set up at https://www.indianactsi.org/ for development. The initial services delivered are:

  • A grant management system for internal CTSI grants
  • A clinical trials listing system
  • A public engagement portal for the Community Health Engagement Program (CHEP)
  • Online educational programs such as training for human subjects research
  • Integrated 'deep web' searches of publications, clinical trials, events, and Hub contributions
  • Federated Identity (InCommon) authentication
  • A searchable database of grants activity
  • An online listing of Indiana CTSI Cores (statewide shared analytical facilities)
  • Identity management for IU, Purdue, and Notre Dame users for all Indiana CTSI Hub applications
  • Private group collaboration tools using Alfresco Share software
  • REDCap Research Data Collection and Management
  • Industry Partner Discovery Tool; launched as i2iconnect.org program
  • Research Technologies Core Services to host Indiana CTSI Hub Completed
  • Project Development Team (PDT) portal Completed
  • Hub website redesign Completed (Anurag Shankar)
  • Volunteer recruitment portal for public to self-identify for clinical trial participation, titled INResearch (https://www.inresearch.org/) Completed (David Altenhof)
  • National Research Networking pilot project, as part of CTSA consortium (William Barnett)
  • Partnership with VIVO grant project to establish institutional faculty profile management Completed (Anurag Shankar)
  • Indiana CTSI e-newsletter project Completed (Anurag Shankar)
  • Expansion of Federated Identity trust environment across all CIC Institutions Completed (William Barnett)
  • VIVO (vivoweb.org) Mini-Grant to develop a linked open data middleware to consume semantic web data such as faculty profiles developed through the VIVO project Completed (Anurag Shankar and Michael Grobe)
  • September 2007: Initial development of Indiana CTSI Hub
  • February 2009: HUBzero Consortium founded by Purdue and IU
  • March 2009: IU pioneers Federated Identity management for Indiana CTSI Hub
  • April 2009: Initial HUBzero workshops at IU
  • September 2009: Establish HUBzero executive committee and plan first meeting
  • Establish Hub development sandbox environment at IU Completed
  • Approve HUBzero Charter; scheduled for fall 2010 in conjunction with the new MOU
  • April 2010: First "HUBub" HUBzero workshop
  • April 2010: Release HUBzero source code
  • June 2010: Indiana CTSI Hub to be hosted by Research Technologies Core Services
  • July 2010: Launch Community Advisory Board
  • October 2010: HUBzero panel at EDUCAUSE Conference (William Barnett with Mike McLennan [Purdue] and Jill Gemmill [Clemson University])
  • November 2010: HUBzero presentation at Supercomputing 2010 (William Barnett with Mike McLennan [Purdue])
  • December 2010: HUBzero tutorial at US-India Network Enabled Research Collaboration Workshop
  • Anurag Shankar has become "HUBzero Evangelist", with goals of improving client relations and software production and release. Ongoing
  • April 5-6, 2011: Hubbub 2011, Indianapolis, IN (https://hubzero.org/hubbub2011)
  • October 11, 2011: HUBzero architecture for Engineering and Life Sciences, CIC Techforum, Champaign, Illinois. (William Barnett and Mike McLennan [Purdue University])
  • October 12, 2011: cceHUB tools for Translational Medicine, Informatics Key Function Committee of the CTSA. (William Barnett and Ann Christine Catlin [Purdue University])
  • October 2011: Semantic tagging of Hub content (Jim Mullen)
  • August 2011: Community Health Engagement Program (CHEP) portal, CTSA2Community.org, funded by a NIH Administrative Supplement to the Indiana CTSI
  • March 2012: HUBzero architectures for Translational Research. AAAS Annual Meeting (William Barnett)
  • May 2012:
    • REDCap reaches 765 users and 604 projects
    • Alfresco Share reaches 1,121 users, 206 sites, and 20,000 documents
    • Implementation of cceHUB collaborative data management workflow tools on the Indiana CTSI Hub; this project is funded by a NIH Administrative Supplement to the Indiana CTSI (William Barnett and Ganesh Shankar)
  • June 2012: Indiana CTSI Hub is the sixth service provider to be accepted into the InCommon Research and Scholarship category for federated identity support
  • August 2012: CTSA2Community Hub has been rebranded CORUS.ORG as part of a strategy by the Indiana CTSI Community Health Engagement Program (CHEP) to establish it as a central resource for community-engaged research best practices.
  • November 2012: HUBzero Consortium has been restructured as an independent 501(c)(3) foundation that will focus on organizing and managing contributions from community sites, and providing a single, non-institutional entity for the assignment of intellectual property. Indiana University is the first university to join this foundation.
  • November 2012: CTSA2Community (CORUS) project Completed (William Barnett and Andrew Arenson)
  • November 2012: DataViewer project for Indiana CTSI Hub Completed (Ganesh Shankar and Michael Grobe)
  • November 2012: Grant Management System software updated (Abhijeet Malatpure)
  • January 2013: Indiana CTSI renewal proposal submitted (Anantha Shekhar, PI)
  • April 18, 2013: 2-5pm, Registries and Clinical Research Symposium, Cancer Research Institute Building (R4), Room 101
  • June 2013: CTSI Navigate Project aimed at helping researchers locate resources deployed
  • July 1, 2013: William Barnett appointed Co-Director, Translational Informatics for the Indiana CTSI. Titus Schleyer, new Director of Medical Informatics at the Regenstrief Institute, is the other Co-Director.
  • July 2013: CTSI Consolidated Biobank Samples Request system is live
  • September 5-7, 2013: Annual HubBub meeting, Indianapolis, IN
  • September 13, 2013: The fifth annual meeting of the Indiana Clinical and Translational Sciences Institute held in Indianapolis
  • October 1, 2013: Indiana CTSI Clinical and Translational Science Award renewed for another 5 years for $30M. Grant: 1UL1 TR001108
  • February 18, 2014: Indiana CTSI withdrew from the HUBzero Consortium.
  • April 15, 2014: Migration process to Joomla! 3.2 started.

Publications:

Weber, Griffin M, William Barnett, Mike Conlon, David Eichmann, Warren Kibbe, Holly Falk-Krzesinski, Michael Halaas, Layne Johnson, Eric Meeks, Donald Mitchell, Titus Schleyer, Sarah Stallings, Michael Warden, Maninder Kahlon, Members of the Direct2Experts Collaboration. 2011. Direct2Experts: a pilot national network to demonstrate interoperability among research-networking platforms, JAMIA doi:10.1136/amiajnl-2011-000200

Berman, Ari E, William K Barnett, and Sean D Mooney, "Collaborative software for traditional and translational research", Human Genomics, 6:21 (25 Sep 2012)

Comment process: Contact William Barnett for general questions. Richard Meraz is project manager for the Indiana CTSI Hub projects.

Benefits: The Indiana CTSI Hub improves the ability of researchers at IU, IUSM, Purdue, and Notre Dame to discover and use translational resources that will serve to catalyze broader ("bench to bedside") research and translation to products that improve health outcomes.

The Hub architecture generally benefits virtual science communities by providing collaborative online tools for undertaking research. It provides research communities with innovative tools for multi-institutional collaboration. It positions IU competitively to lead national virtual research organizations. It also provides a ready environment to develop the next generation of web-based research tools for collaborative science.

Client impact: Primary clients include IU, Purdue, and Notre Dame health care researchers and ultimately practitioners, industry partners, and the public across Indiana. Secondary clients include researchers at other CTSAs across the country.

Related information: Clinical and Translational Science Awards

Aids achievement of the following Empowering People actions:

  • Recommendation A1
    • Action 4: Cyberinfrastructure. IU should continue to advance its local cyberinfrastructure, participation in national cyberinfrastructure, and its efforts to win federal funding of cyberinfrastructure programs that enhance IU's research capabilities.
    • Action 6: Leveraging partnerships. IU should continue its highly successful program of relationships with hardware, software, and services vendors, and seek additional partnerships and creative exchanges that provide mutual benefits.
  • Recommendation A4
    • Action 16: External funding. OVPIT should continue to lead and expand its efforts to effectively partner with academic units, campuses, administrative units, or individual investigators for external funding opportunities.
  • Recommendation C15
    • Action 70: IT-enabled research. IU should purposefully select areas of great and timely promise for strategic development of IT-enabled research, scholarship, and/or creative activity.
    • Action 71: IT-enabled research resources. IU should identify a base of resources to provide both initial and sustained investments in selected areas for IT-enabled research, scholarship, and/or creative activity. This may include reallocating current resources and developing new ones, including endowments, grants, and/or additional fees.

UITS project team:

  • William K. Barnett, Director, Advanced Biomedical IT Core (Project Director)
  • Richard Meraz, Manager, Advanced Biomedical IT Core (Project Manager)
  • James Dudley, Advanced Biomedical IT Core
  • Abhijeet Malatpure, Advanced Biomedical IT Core

Principal Indiana CTSI collaborators:

  • Lilith Reeves, Chief Scientist, Indiana CTSI, IUSM
  • Samantha Scahill, Office of the Director, Indiana CTSI
  • Joe Hunt, Indiana CTSI Evaluation Program
  • Bob Davis, Biostatistics Department, IUSM
  • Elaine Skopelja, IUSM Library
  • Beth Whipple, IUSM Library
  • Jere Odell, Bioethics Program, IUSM
  • Karen Comer, POLIS Center
  • Melanie DeFord, Notre Dame
  • Bill Hetrick, IU Bloomington

Governance:

  • UITS project sponsor: Craig Stewart, Associate Dean for Research Technologies
  • Indiana CTSI project sponsor: Anantha Shekhar, Director, Indiana CTSI, IUSM

This is document axcg in the Knowledge Base.
Last modified on 2017-08-28 16:14:13.

  • Fill out this form to submit your issue to the UITS Support Center.
  • Please note that you must be affiliated with Indiana University to receive support.
  • All fields are required.

Please provide your IU email address. If you currently have a problem receiving email at your IU account, enter an alternate email address.

  • Fill out this form to submit your comment to the IU Knowledge Base.
  • If you are affiliated with Indiana University and need help with a computing problem, please use the I need help with a computing problem section above, or contact your campus Support Center.

Please provide your IU email address. If you currently have a problem receiving email at your IU account, enter an alternate email address.